Proton Beam Radiation Therapy after Treatment for Resected N2 Non-Small Cell Lung Cancer

Active:	Yes
Cancer Type:	Lung Cancer	NCT ID:	NCT06008730
Trial Phases:	Phase I	Protocol IDs:	RAD5621-22 (primary) NCI-2023-02941 STUDY00005105
Eligibility:	18 Years and older, Male and Female	Study Type:	Treatment
Study Sponsor:	Emory University Hospital/Winship Cancer Institute
NCI Full Details:	http://clinicaltrials.gov/show/NCT06008730

Summary

This clinical trial tests proton beam radiation therapy in patients after treatment for N2 non-small cell lung cancer that has been removed by surgery (resected). Proton therapy is a kind of radiation used to treat cancer. Like other types of radiation, proton therapy kills cancer cells and stops them from growing. Proton beam therapy is sometimes used after cancer surgery to reduce the risk of cancer recurrence (coming back). Giving proton beam radiation therapy may work better after surgery in patients with resected non-small cell lung cancer compared to conventional radiation treatment.

Objectives

PRIMARY OBJECTIVE:
I. To assess the safety of proton beam radiation therapy (PBRT) for resected N2 non-small cell lung cancer (NSCLC).

SECONDARY OBJECTIVES:
I. To measure the radiation dose to the circulating immune compartment and explore its association with clinical endpoints.
II. To assess the efficacy of PBRT for resected N2 NSCLC.

OUTLINE:
Patients undergo radiation treatment planning and then undergo proton beam radiation therapy, over 27-30 treatments, in the absence of disease progression or unacceptable toxicity. Patients also undergo collection of blood samples throughout the study and computed tomography (CT) or positron emission tomography (PET)/CT during follow-up.

Patients are followed up for 24 months after first dose of radiotherapy.

Treatment Sites in Georgia

Emory Proton Therapy Center
615 Peachtree Street NE
Atlanta, GA 30308
winshipcancer.emory.edu/proton-therapy-center/

Winship Cancer Institute of Emory University
1365 Clifton Road NE
Building C
Atlanta, GA 30322
winshipcancer.emory.edu

**Clinical trials are research studies that involve people. These studies test new ways to prevent, detect, diagnose, or treat diseases. People who take part in cancer clinical trials have an opportunity to contribute to scientists’ knowledge about cancer and to help in the development of improved cancer treatments. They also receive state-of-the-art care from cancer experts... Click here to learn more about clinical trials.