DB-1311 in Combination With BNT327 or DB-1305 in Advanced/Metastatic Solid Tumors

Active:	Yes
Cancer Type:	Cervical Cancer Liver Cancer / Hepatoblastoma Lung Cancer Melanoma	NCT ID:	NCT06953089
Trial Phases:	Phase II	Protocol IDs:	DB-1311-201 (primary) NCI-2025-05085
Eligibility:	18 Years and older, Male and Female	Study Type:	Treatment
Study Sponsor:	DualityBio Inc.
NCI Full Details:	http://clinicaltrials.gov/show/NCT06953089

Summary

A Phase II, Multicenter, Open-Label Trial of DB-1311 in combination with BNT327 or
DB-1305 in Participants with Advanced/Metastatic Solid Tumors

Objectives

This is a phase II, multicenter, open-label, two-part trial designed to evaluate the
safety and preliminary efficacy of DB-1311 in combination with BNT327 or DB-1311 in
combination with DB-1305 in targeted participants.

Participants with recurrent, progressive as well as advanced, metastatic hepatocellular
carcinoma (HCC), cervical cancer (CC), melanoma, head and neck squamous cell carcinoma
(HNSCC), platinum-resistant ovarian cancer (PROC) or non-small cell lung cancer (NSCLC)
are eligible to participate in the trial.

Treatment Sites in Georgia

Piedmont Cancer Institute - Atlanta
1800 Howell Mill Road
Suite 800
Atlanta, GA 30318
678-298-3238
www.piedmontcancerinstitute.com

Doctors:

Vasily J. Assikis MD

William S. Jonas MD

Eric D. Mininberg MD

Ha N. Tran MD

Rajni Sinha MD

Jay Rhee MD

Samantha Shams MD

Nikita Tushar Amin MD

Piedmont Cancer Institute - Fayetteville
1267 Highway 54 West
Suite 4200
Fayetteville, GA 30214
678-298-3238
www.piedmontcancerinstitute.com

Doctors:

Jonathan C. Bender MD

Trevor M. Feinstein MD

Vipin Ramprasad Lohiya MD

Piedmont Cancer Institute – Locust Grove
4877 Bill Gardner Pkwy
Locust Grove, GA 30248
www.piedmontcancerinstitute.com

Piedmont Cancer Institute - Newnan
775 Poplar Road
Suite 310
Newnan, GA 30265
678-298-3238
www.piedmontcancerinstitute.com

Doctors:

Vasily J. Assikis MD

Minesh D. Patel MD

Nikita Tushar Amin MD

Piedmont Cancer Institute – Sandy Springs
755 Mount Vernon Hwy
Suite 320
Atlanta, GA 30328
www.piedmontcancerinstitute.com

Piedmont Cancer Institute - Stockbridge
290 Country Club Drive
Suite 100
Stockbridge, GA 30281
678-298-3238
www.piedmontcancerinstitute.com

Doctors:

Eric D. Mininberg MD

Ha N. Tran MD

Vipin Ramprasad Lohiya MD

**Clinical trials are research studies that involve people. These studies test new ways to prevent, detect, diagnose, or treat diseases. People who take part in cancer clinical trials have an opportunity to contribute to scientists’ knowledge about cancer and to help in the development of improved cancer treatments. They also receive state-of-the-art care from cancer experts... Click here to learn more about clinical trials.