AZD0901 Compared With Investigator's Choice of Therapy in Participants With Second- or Later-line Advanced or Metastatic Gastric or Gastroesophageal Junction Adenocarcinoma Expressing Claudin18.2

Active:	Yes
Cancer Type:	Esophogeal Cancer Stomach/ Gastric Cancer Unknown Primary	NCT ID:	NCT06346392
Trial Phases:	Phase III	Protocol IDs:	D9802C00001 (primary) NCI-2024-05552
Eligibility:	18 - 130 Years, Male and Female	Study Type:	Treatment
Study Sponsor:	AstraZeneca Pharmaceuticals LP
NCI Full Details:	http://clinicaltrials.gov/show/NCT06346392

Summary

The purpose of this study is to measure the efficacy and safety of AZD0901 compared to
Investigator's choice of therapy as 2L+ treatment for participants with advanced or
metastatic gastric or GEJ adenocarcinoma expressing CLDN18.2.

Objectives

This is a Phase III, multi-center, open-label, sponsor-blinded, randomized, global study
to assess the efficacy and safety of AZD0901 compared to Investigator's choice of therapy
as the 2L+ treatment for participants with advanced or metastatic gastric or GEJ
adenocarcinoma expressing CLDN18.2, and the clinical performance of the investigational
IVD. As part of this combined approach, the efficacy analyses from this study will also
provide the basis to evaluate the clinical performance of Ventana CLDN18.2 assay as an
IVD device for the identification of patients with advanced or metastatic gastric or GEJ
adenocarcinoma expressing CLDN18.2 who may benefit from AZD0901.

Treatment Sites in Georgia

Northwest Georgia Oncology Centers - Austell
1700 Hospital South Drive
Suite 300
Austell, GA 30106
770-281-5131
www.ngoc.com

Doctors:

Sujatha Hariharan MD

Carlos A. Osmon MD

Northwest Georgia Oncology Centers - Bremen
200 Allen Memorial Drive
Suite 302-B
Bremen, GA 30110
770-281-5131
www.ngoc.com

Doctors:

Bradley J.G. Larson MD

Northwest Georgia Oncology Centers - Carrollton
157 Clinic Avenue
Suite 101
Carrollton, GA 30117
770-281-5131
www.ngoc.com

Doctors:

Bradley J.G. Larson MD

Randall E. Pierce MD

Northwest Georgia Oncology Centers - Cartersville
100 Market Place Boulevard
Suite 200
Cartersville, GA 30121
770-281-5131
www.ngoc.com

Doctors:

Satyen R. Mehta MD

Madhurima Uppalapati MD

Northwest Georgia Oncology Centers - Douglasville
6002 Professional Parkway
Suite 220
Douglasville, GA 30134
770-281-5131
www.ngoc.com

Doctors:

Navin P. Wadehra MD

Aron E. Kefela MD

Northwest Georgia Oncology Centers - Jasper
1020 J.L. White Drive
Suite 160
Jasper, GA 30143
770-281-5131
www.ngoc.com

Doctors:

Curtis R. Miles MD

Northwest Georgia Oncology Centers - Marietta
340 Kennestone Hospital Boulevard
Suite 200
Marietta, GA 30060
770-281-5131
www.ngoc.com

Northwest Georgia Oncology Centers - Paulding
144 Bill Carruth Parkway
Suite 3100
Hiram, GA 30141
770-281-5131
www.ngoc.com

Doctors:

Kathleen A. Long MD

Aron E. Kefela MD

Northwest Georgia Oncology Centers - Villa Rica
705 Dallas Highway
Suite 204
Villa Rica, GA 30180
770-281-5131
www.ngoc.com

Doctors:

Randall E. Pierce MD

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