Mirvetuximab Soravtansine With Bevacizumab Versus Bevacizumab as Maintenance in Platinum-sensitive Ovarian, Fallopian Tube, or Peritoneal Cancer (GLORIOSA)

Active:	Yes
Cancer Type:	Gynecologic Cancers Ovarian Cancer Primary Peritoneal Cancer Unknown Primary	NCT ID:	NCT05445778
Trial Phases:	Phase III	Protocol IDs:	IMGN853-0421 (primary) NCI-2023-00369
Eligibility:	18 Years and older, Male and Female	Study Type:	Treatment
Study Sponsor:	ImmunoGen Inc
NCI Full Details:	http://clinicaltrials.gov/show/NCT05445778

Summary

GLORIOSA is a Phase 3 multicenter, open label study designed to evaluate the safety and
efficacy of mirvetuximab Soravtansine as maintenance therapy in participants with
platinum-sensitive ovarian, primary peritoneal or fallopian tube cancers with high folate
receptor-alpha (FRa) expression.

Objectives

Mirvetuximab Soravtansine (MIRV) is an investigational antibody drug conjugate designed
to selectively kill cancer cells. The antibody (protein) part of MIRV targets tumors by
delivering a cell-killing drug to the tumor cells carrying a tumor-associated protein
called folate receptor alpha (FRa). It is being developed as maintenance therapy for the
treatment of subjects with recurrent platinum-sensitive, highgrade epithelial ovarian,
primary peritoneal, or fallopian tube cancers with high folate receptor-alpha expression.
Patients must have confirmation of FRa positivity by the Ventana FOLR1 Assay.

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Treatment Sites in Georgia

Northside Hospital Cancer Institute
1000 Johnson Ferry Road NE
Atlanta, GA 30342
404-303-3355
www.northside.com

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