Study of Tirabrutinib (ONO-4059) in Patients With Primary Central Nervous System Lymphoma (PROSPECT Study)

Active:	Yes
Cancer Type:	Brain & Spinal Cord Tumor Hematopoietic Malignancies Lymphoma Unknown Primary	NCT ID:	NCT04947319
Trial Phases:	Phase II	Protocol IDs:	ONO-4059-09 (primary) NCI-2021-14196
Eligibility:	18 Years and older, Male and Female	Study Type:	Treatment
Study Sponsor:	Ono Pharmaceutical Company Limited
NCI Full Details:	http://clinicaltrials.gov/show/NCT04947319

Summary

This study will evaluate the efficacy, safety, and pharmacokinetics of tirabrutinib
monotherapy in patients with relapsed or refractory PCNSL (Part A), and tirabrutinib in
combination with one of two different high dose methotrexate based regimens
(methotrexate/ temozolomide/rituximab or rituximab/methotrexate/procarbazine/
vincristine) as first line therapy in patients with newly diagnosed, treatment naïve
PCNSL (Part B)

Treatment Sites in Georgia

Winship Cancer Institute of Emory University
1365 Clifton Road NE
Building C
Atlanta, GA 30322
winshipcancer.emory.edu

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