A Study Comparing Abelacimab to Dalteparin in the Treatment of Gastrointestinal/Genitourinary Cancer and Associated VTE

Active:	Yes
Cancer Type:	Unknown Primary	NCT ID:	NCT05171075
Trial Phases:	Phase III	Protocol IDs:	ANT-008 (primary) NCI-2022-08854 2021-003085-12
Eligibility:	18 Years and older, Male and Female	Study Type:	Treatment
Study Sponsor:	Anthos Therapeutics, Inc.
NCI Full Details:	http://clinicaltrials.gov/show/NCT05171075

Summary

This is a Phase 3, multicenter, open-label, blinded endpoint study to evaluate the effect
of abelacimab relative to dalteparin on venous thromboembolism (VTE) recurrence and
bleeding in patients with gastrointestinal (GI)/genitourinary (GU) cancer associated VTE
(Magnolia)

Objectives

Cancer associated thrombosis (CAT) is a severe medical condition which is characterized
by high incidence of Venous thromboembolism (VTE) recurrence and high risk for bleeding.
Patients with intact GI and GU cancer have increased bleeding risk with oral direct
anticoagulants (DOACs), Guidelines advice caution with those DOACs or state preference
for low molecular weight heparin (LMWH) in this population. The ANT-008 study will
compare treatment with abelacimab monthly administration to LMWH daily subcutaneous (sc)
administration over 6-month treatment. The study outcomes include VTE recurrence,
bleeding event and treatment discontinuation at 6 months

Treatment Sites in Georgia

Winship Cancer Institute of Emory University
1365 Clifton Road NE
Building C
Atlanta, GA 30322
winshipcancer.emory.edu

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