Childhood Cancer Predisposition Study

Active:	Yes
Cancer Type:	Cancer-Related Syndrome	NCT ID:	NCT04511806
Trial Phases:		Protocol IDs:	CHOA4972-20 (primary) NCI-2020-01621 STUDY00000109
Eligibility:	0 - 21 Years, Male and Female	Study Type:	Other
Study Sponsor:	Children's Healthcare of Atlanta - Egleston
NCI Full Details:	http://clinicaltrials.gov/show/NCT04511806

Summary

This study collects data to create a multicenter registry and biorepository. Studying individuals at high risk for childhood cancer may help doctors to understand carcinogenesis, tumor surveillance, early detection, and cancer prevention, which may collectively contribute to improving care and outcomes for pediatric patients with cancer and those with cancer predisposition syndromes.

Objectives

PRIMARY OBJECTIVES:
I. To establish and maintain a framework for recruitment, participation, and surveillance of children with cancer predisposition syndromes (CPS) in clinical and translational research studies.
II. To define the natural history of disease in children with CPS.
II. To evaluate the clinical impact and effectiveness of standard and emerging tumor surveillance strategies.

OUTLINE:
All participants undergo collection of blood, saliva, or buccal swab for germline deoxyribonucleic acid (DNA). Primary subjects also undergo collection of blood annually, leftover tumor tissue (optional), and radiologic imaging files. Primary subjects' medical data is abstracted.

**Clinical trials are research studies that involve people. These studies test new ways to prevent, detect, diagnose, or treat diseases. People who take part in cancer clinical trials have an opportunity to contribute to scientists’ knowledge about cancer and to help in the development of improved cancer treatments. They also receive state-of-the-art care from cancer experts... Click here to learn more about clinical trials.