HLA-Mismatched Unrelated Donor Hematopoietic Cell Transplantation With Post-Transplantation Cyclophosphamide

Active:	Yes
Cancer Type:	Cancer-Related Syndrome Leukemia Lymphoma Myelodysplastic Syndromes (MDS)	NCT ID:	NCT04904588
Trial Phases:	Phase II	Protocol IDs:	ACCESS (primary) NCI-2021-06605
Eligibility:	1 Years and older, Male and Female	Study Type:	Treatment
Study Sponsor:	Center for International Blood and Marrow Transplant Research
NCI Full Details:	http://clinicaltrials.gov/show/NCT04904588

Summary

This is a prospective, multi-center, Phase II study of hematopoietic cell transplantation
(HCT) using human leukocyte antigen (HLA)-mismatched unrelated donors (MMUD) for
peripheral blood stem cell transplant in adults and bone marrow stem cell transplant in
children. Post-transplant cyclophosphamide (PTCy), tacrolimus and mycophenolate mofetil
(MMF) will be used for for graft versus host disease (GVHD) prophylaxis. This trial will
study how well this treatment works in patients with hematologic malignancies.

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