Safety and Efficacy of bb2121 (Ide-cel) Combinations in Multiple Myeloma

Active:	No
Cancer Type:	Multiple Myeloma	NCT ID:	NCT04855136
Trial Phases:	Phase I Phase II	Protocol IDs:	BB2121-MM-007 (primary) NCI-2021-07135 2020-003248-10
Eligibility:	18 Years and older, Male and Female	Study Type:	Treatment
Study Sponsor:	Celgene
NCI Full Details:	http://clinicaltrials.gov/show/NCT04855136

Summary

This is a global, open-label, multi-arm, multi-cohort, multi-center, phase 1/2 study to
determine the safety, tolerability, efficacy, PK of bb2121 in combination with other
therapies in adult subjects with R/RMM.

The following combinations will be

- Arm A will test bb2121 in combination with CC-220 (± low-dose dexamethasone)

- Arm B will test bb2121 in combination with BMS-986405 (JSMD194)

Combination agents being tested may be administered before, concurrently with and/or
following (ie, maintenance) bb2121 infusion.

The study will consist of 2 parts: dose finding (Phase 1) and dose expansion (Phase 2).
Dose expansion may occur in one or more arms.

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