A Study of TSR-022 in Participants With Advanced Solid Tumors (AMBER)

Active:	Yes
Cancer Type:	Colon/Rectal Cancer Lung Cancer Melanoma	NCT ID:	NCT02817633
Trial Phases:	Phase I	Protocol IDs:	4020-01-001 (primary) NCI-2016-01254
Eligibility:	18 Years and older, Male and Female	Study Type:	Treatment
Study Sponsor:	Tesaro Inc
NCI Full Details:	http://clinicaltrials.gov/show/NCT02817633

Summary

This is a first-in-human study evaluating the anti-T cell immunoglobulin and mucin
containing protein-3 (TIM-3) antibody TSR-022. The study will be conducted in 2 parts
with Part 1 consisting of dose escalation and Part 2 dose expansion. Part 1 will
determine the recommended Phase 2 dose (RP2D) of TSR-022 and Part 2 will evaluate the
antitumor activity of TSR-022 in combination with TSR-042 or docetaxel and as
monotherapy.

Treatment Sites in Georgia

Winship Cancer Institute of Emory University
1365 Clifton Road NE
Building C
Atlanta, GA 30322
winshipcancer.emory.edu

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